| Bioactivity | 9-β-D-Arabinofuranosylguanine is a Guanosine (HY-N0097) analog and shows high affinity for deoxyguanosine kinase (dGK) with a Km of 8.0 μM. 9-β-D-Arabinofuranosylguanine can be used for the research of T-cell lymphoblastic disease[1][2]. |
| Target | Km: 8.0 μM (dGK) |
| Invitro | 9-β-D-Arabinofuranosylguanine 通过其 5 ' -三磷酸腺苷 Ara-GTP 在细胞内的积累引起细胞毒性，Ara-GTP 抑制 DNA 聚合酶和核糖核苷酸还原酶，并入 DNA，终止 DNA 链伸长，导致细胞死亡[1][2]。9-β-D-Arabinofuranosylguanine 对培养的 T 淋巴母细胞具有选择性毒性，因为相对于 B- 和无淋巴母细胞，它们能够积累更高水平的细胞毒性代谢物 Ara-GTP[1]。9-β-D-Arabinofuranosylguanine (0-1000 μM; 72 h) 具有细胞毒性，对 MOLT-4、MOLT-4/Ara-G500 和 MOLT-4/Ara-G900 的 IC50 分别为 4.2、452 和 777 μM[2]。 Cell Viability Assay[2] Cell Line: |
| Name | 9-β-D-Arabinofuranosylguanine |
| CAS | 38819-10-2 |
| Formula | C10H13N5O5 |
| Molar Mass | 283.24 |
| Appearance | Solid |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) |
| Reference | [1]. Shewach DS, et al. Differential metabolism of 9-beta-D-arabinofuranosylguanine in human leukemic cells. Cancer Res. 1989 Dec 1;49(23):6498-502. [2]. Lotfi K, et al. Low level of mitochondrial deoxyguanosine kinase is the dominant factor in acquired resistance to 9-beta-D-arabinofuranosylguanine cytotoxicity. Biochem Biophys Res Commun. 2002 May 24;293(5):1489-96. |
9-β-D-Arabinofuranosylguanine
CAS: 38819-10-2 F: C10H13N5O5 W: 283.24
9-β-D-Arabinofuranosylguanine is a Guanosine (HY-N0097) analog and shows high affinity for deoxyguanosine kinase (dGK)
Sales Email：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.