| Bioactivity | 4,9-Anhydrotetrodotoxin is a selective voltage-gated sodium channel (VGSC) inhibitor that blocks Nav1.1 and Nav1.6 in human brain and induces a hyperpolarizing shift in the voltage dependence of inactivated Nav1.6[1]. |
| Invitro | 4,9-Anhydrotetrodotoxin (0.01-10000 nM) results in significant blockade of Nav1.6-mediated Na current in the nanomolar range, it also has significant effects on Nav1.1-mediated Na current in human brain sample[1]. |
| Name | 4,9-Anhydrotetrodotoxin |
| CAS | 13072-89-4 |
| Formula | C11H15N3O7 |
| Molar Mass | 301.25 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Nicholas Denomme, et al. The voltage-gated sodium channel inhibitor, 4,9-anhydrotetrodotoxin, blocks human Nav1.1 in addition to Nav1.6. Neurosci Lett. 2020 Apr 17;724:134853. |
4,9-Anhydrotetrodotoxin
CAS: 13072-89-4 F: C11H15N3O7 W: 301.25
4,9-Anhydrotetrodotoxin is a selective voltage-gated sodium channel (VGSC) inhibitor that blocks Nav1.1 and Nav1.6 in hu
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