| CAS | 133407-83-7 |
| Sequence | Z-Leu-Leu-Nle-aldehyde |
| Sequence Single | Z-LLnL-CHO |
| Molecular Formula | C26H41N3O5 |
| Molecular Weight | 475.63 |
| Synonyms | γ-Secretase Inhibitor I |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | Alzheimer’s Disease |
| Description | Z-Leu-Leu-Nle-aldehyde (Z-LLnL-CHO) is a γ-secretase inhibitor I. Z-Leu-Leu-Nle-aldehyde induces caspase and ROS-dependent apoptosis by blocking the Akt-mediated pro-survival pathway. Z-Leu-Leu-Nle-aldehyde can be used in cancer research, such as breast cancer and leukaemia. |
| References | 1. The cytotoxicity of gamma-secretase inhibitor I to breast cancer cells is mediated by proteasome inhibition, not by gamma-secretase inhibition. Han J, et al. Breast Cancer Res. 2009;11(4):R57. 2. GSI-I (Z-LLNle-CHO) inhibits γ-secretase and the proteosome to trigger cell death in precursor-B acute lymphoblastic leukemia. Meng X, et al. Leukemia. 2011 Jul;25(7):1135-46. |