| CAS | 161710-10-7 |
| Sequence | Z-Ile-Leu-aldehyde |
| Sequence Single | Z-IL-aldehyde |
| Molecular Formula | C20H30N2O4 |
| Molecular Weight | 362.47 |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | Alzheimer’s Disease |
| Description | Z-Ile-Leu-aldehyde also called Z-IL-CHO, a cell-permeable, reversible inhibitor, reduces amyloid β (Aβ)-production by blocking γ-secretase activity in vitro (Aβ40 IC50 = 7.9 µM; Aβ42 IC50 = 7.6 µM). Besides blocking the formation of Aβ the dipeptide aldehyde Z-IL-CHO also blocks the production of the γ-CTF (γ-secretase-generated carboxyl-terminal fragment), but does not affect the formation of amyloid-β-precursor protein (APP). |
| References | 1. Human stresscopin and stresscopin-related peptide are selective ligands for the type 2 corticotropin-releasing hormone receptor. S.Y.Hsu and A.J.Hsueh, Nat. Med., 7, 605 (2001) 2. Activation of Notch-1 signaling maintains the neoplastic phenotype in human Ras-transformed cells. S.Weijzen et al., Nat. Med., 8, 979 (2002) 3. The Role Of Notch In Th17 Differentiation. Reem Suleiman, et al. University of Massachusetts Amherst. 9-2013. 4. Notch pathway inhibition controls myeloma bone disease in the murine MOPC315.BM model. Schwarzer R, et al. Blood Cancer J. 2014 Jun 13;4:e217. |