| CAS | 144092-28-4 |
| Sequence | H-Met-Leu-Thr-Lys-Phe-Glu-Thr-Lys-Ser-Ala-Arg-Val-Lys-Gly-Leu-Ser-Phe-His-Pro-Lys-Arg-Pro-Trp-Ile-Leu-OH |
| Sequence Single | MLTKFETKSARVKGLSFHPKRPWIL |
| Molecular Formula | C139H224N38O32S |
| Molecular Weight | 2971.61 |
| Synonyms | Xenin |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | Diabetes |
| Description | Xenin 25 also called Xenin, which has 6 C-terminal amino acids in common with amphibian xenopsin, has been detected in human gastric mucosa. Xenin 25 stimulates the exocrine pancreatic secretion. Xenin co-excreted with the incretin GIP has gained interest in diabetes research. |
| References | 1. Vasoactive intestinal peptide potentiates sexual behavior: inhibition by novel antagonist. I.Gozes et al., Endocrinology, 125, 2945 (1989) 2. Xenin-25 amplifies GIP-mediated insulin secretion in humans with normal and impaired glucose tolerance but not type 2 diabetes. B.Wice et al., Diabetes, 61, 1793 (2012) 3. Characterisation of the biological activity of xenin-25 degradation fragment peptides. C.M.Martin et al., J. Endocrinol., 221, 193 (2014) 4. Xenin plasma concentrations during modified sham feeding and during meals of different composition demonstrated by radioimmunoassay and chromatography. G.E.Feurle et al., Regul. Pept., 111, 153 (2003) 5. Gastroenteropancreatic effects of xenin in the dog. G.E.Feurle et al., J. Pept. Res., 49, 324 (1997) 6. Identification of xenin, a xenopsin-related peptide, in the human gastric mucosa and its effect on exocrine pancreatic secretion. G.E.Feurle et al., J. Biol. Chem., 267, 22305 (1992) 7. Xenin-25 delays gastric emptying and reduces postprandial glucose levels in humans with and without type 2 diabetes. S.Chowdhury et al., Am. J. Physiol. Gastrointest. Liver Physiol., 306, G301 (2014) |