| CAS | 1370290-58-6 |
| Sequence | H-Asn-Trp-Thr-Pro-Gln-Ala-Met-Leu-Tyr-Leu-Lys-Gly-Ala-Gln-NH2 |
| Sequence Single | NWTPQAMLYLKGAQ-NH2 |
| Molecular Formula | C74H114N20O19S |
| Molecular Weight | 1619.91 |
| Synonyms | Spexin/NPQ human, mouse, bovine |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | Gastrointestinal Research |
| Description | Spexin (SPX, also called NPQ) is a conserved peptide plays roles of neurotransmitter/neuromodulator and endocrine factor. Spexin peptide contains numerous aromatic amino acids and is probably amidated. Spexin is a gastro-intestinal peptide hormone. In situ hybridization localized its mRNA to the stomach and esophagus. Synthetic spexin induced dose-dependent contraction of stomach muscle, suggesting that it is involved in digestion. The results obtained by Rucinski et al. indicate that spexin may inhibit adrenocortical cell proliferation. |
| References | 1. Effect of two synthetic alpha-gliadin peptides on lymphocytes in celiac disease: identification of a novel class of opioid receptors. L.Graf et al., Neuropeptides, 9, 113 (1987) 2. Expression of the spexin gene in the rat adrenal gland and evidences suggesting that spexin inhibits adrenocortical cell proliferation. M.Rucinski et al., Peptides, 31, 676 (2010) 3. Spexin expression in normal rat tissues. A.Porzionato et al., J. Histochem. Cytochem., 58, 825 (2010) |