| CAS | 251293-28-4 |
| Sequence | H-Glu-Thr-Pro-Asp-Cys-Phe-Trp-Lys-Tyr-Cys-Val-OH (Disulfide bond) |
| Sequence Single | ETPDCFWKYCV |
| Molecular Formula | C64H85N13O18S2 |
| Molecular Weight | 1388.59 |
| Synonyms | U-II (human) |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | Cardiovascular System & Diseases |
| Description | Urotensin II (human) also called U-II (human), is a vasoactive somatostatin-like cyclic peptide, which has long been regarded as a peptide exclusively produced by the urophysis of teleost fish. U-II has also been cloned from man. Urotensin II (human) was found to be the most potent mammalian vasoconstrictor identified so far. Furthermore, as urotensin II immunoreactivity was also found within central nervous system and endocrine tissues, it may have additional activities. Urotensin II (human) is a agonist for the orphan receptor GPR14. |
| References | 1. An Efficient Procedure for Solid-Phase Synthesis of Phosphopeptides by the Fmoc Strategy. T.Wakamiya et al., Chem. Lett., 23, 1099 (1994) 2. Cloning of the cDNA encoding the urotensin II precursor in frog and human reveals intense expression of the urotensin II gene in motoneurons of the spinal cord. Y.Coulouarn et al., Proc. Natl. Acad. Sci. USA, 95, 15803 (1998) 3. Human urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14. Ames RS, et al. Nature. 1999 Sep 16;401(6750):282-6. |