| CAS | 135306-85-3 |
| Sequence | H-Asp-Tyr-D-Trp-Val-D-Trp-D-Trp-Lys-NH2 |
| Sequence Single | DYwVwwK-NH2 |
| Molecular Formula | C57H68N12O10 |
| Molecular Weight | 1081.24 |
| Synonyms | MEN 10376 |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Description | (Tyr5,D-Trp6.8.9,Lys-NH₂¹⁰)-Neurokinin A (4-10) also called MEN 10376, is a selective tachykinin NK-2 receptor antagonist, with a Ki of 4.4 μM for rat small intestine NK-2 receptor. |
| References | 1. Substrate specificity and kinetic characteristics of angiotensin converting enzyme. P.Bünning et al., Biochemistry, 22, 103 (1983) 2. In vivo evidence for tachykininergic transmission using a new NK-2 receptor-selective antagonist, MEN 10,376. R.Patacchini et al., Br. J. Pharmacol., 104 (Proc. Suppl.), 145P (1991) 3. N-terminal truncated analogs of men 10376 as tachykinin NK-2 receptor antagonists. Quartara L, et al. Life Sci. 1992;51(25):1929-36. |
(Tyr5,D-Trp6.8.9,Lys-NH₂¹⁰)-Neurokinin A (4-10)
CAS No.: 135306-85-3
(Tyr5,D-Trp6.8.9,Lys-NH₂¹⁰)-Neurokinin A (4-10) also called MEN 10376, is a selective tachykinin NK-2 receptor antago
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