| CAS | 848442-59-1 |
| Sequence | H-Gly-Ser-Trp-Phe-Arg-OH |
| Sequence Single | GSWFR |
| Molecular Formula | C31H41N9O7 |
| Molecular Weight | 651.72 |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | Obesity Research |
| Description | (Trp3,Arg5)-Ghrelin (1-5) is a growth hormone secretagogue (GSH) receptor agonist based on the primary structure of ghrelin (IC50 = 10 µM). (Trp3,Arg5)-Ghrelin (1-5) (GSWFR) stimulated growth hormone secretion after intravenous or oral administration and centrally administered (Trp3,Arg5)-Ghrelin (1-5) increased food intake in non-fasted mice. The orexigenic effect could be inhibited by (D-Lys3)-GHRP-6 and also by the NPY Y3 receptor antagonist BIBO3304 suggesting that GSWFR-induced feeding is mediated by the NPY Y3 receptor. |