(Des-octanoyl)-Ghrelin (human) Ghrelin and Obestatin Catalog

CAS	313951-59-6
Sequence	H-Gly-Ser-Ser-Phe-Leu-Ser-Pro-Glu-His-Gln-Arg-Val-Gln-Gln-Arg-Lys-Glu-Ser-Lys-Lys-Pro-Pro-Ala-Lys-Leu-Gln-Pro-Arg-OH
Sequence Single	GSSFLSPEHQRVQQRKESKKPPAKLQPR
Molecular Formula	C141H235N47O41
Molecular Weight	3244.71
Synonyms	(Des-octanoyl)-Ghrelin, human
Technology	Synthetic
Storage	-20°C, avoid light, cool and dry place
Application	Obesity Research
Description	(Des-octanoyl)-Ghrelin (human) also called (Des-octanoyl)-Ghrelin, human, is a non-acylated, major circulating isoform of ghrelin that does not bind to the ghrelin receptor (GHS-R1a), nor induce growth hormone release. However, exerts negative inotropic effects in papillary muscle and displays cardioprotective activity. Inhibits cell proliferation in breast and prostate cancer cell lines. Promotes adipogenesis in vivo.
References	1. Excitatory action of [Leu13]motilin on the gastrointestinal smooth muscle isolated from the chicken. T.Kitazawa et al., Peptides, 16, 1243 (1995) 2. Meal intake similarly reduces circulating concentrations of octanoyl and total ghrelin in humans. P.Lucidi et al., J. Endocrinol. Invest., 27, RC12 (2004) 3. Non-acylated ghrelin does not possess the pituitaric and pancreatic endocrine activity of acylated ghrelin in humans. F.Broglio et al., J. Endocrinol. Invest., 26, 192 (2003)

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