| Description |
TRH also called Thyroliberin, Prolactoliberin, Prolactostatin, Protirelin, Thyrotropin-Releasing Hormone, exhibits a variety of biological effects, when injected into humans or animals. Its physiological role appears to be the stimulation of thyrotropin (TSH) and prolactin (PRL) release from the anterior pituitary. Though it was first identified in the hypothalamus as a regulator of the pituitary-thyroid axis, TRH was detected as well by Luo et al. in pancreatic β-cells co-localized with insulin. Application of the hormone reverted hyperglycemia in rats. Moreover, TRH plays an important role in the control of human hair-growth and hair follicle pigmentation. |
| References |
1.
Antihypertensive effect of sour milk and peptides isolated from it that are inhibitors to angiotensin I-converting enzyme.
Y.Nakamura et al., J. Dairy Sci., 78, 1253 (1995)
2.
TRH decreases food intake and increases water intake and body temperature in rats.
Y.H.Choi et al., Physiol. Behav., 77, 1 (2002)
3.
Thyrotropin-releasing hormone (TRH) in the neuroaxis: therapeutic effects reflect physiological functions and molecular actions.
G.G.Yarbrough et al., Med. Hypotheses, 69, 1249 (2007)
4.
Hypothalamic regulatory hormones.
A.V.Schally et al., Annu. Rev. Biochem., 47, 89 (1978)
5.
Hypothalamic hormones.
S.Reichlin et al., Annu. Rev. Physiol., 38, 389 (1976)
6.
Thyrotropin-releasing hormone (TRH) reverses hyperglycemia in rat.
L.Luo et al., Biochem. Biophys. Res. Commun., 374, 69 (2008)
7.
Thyrotropin releasing hormone (TRH) affects gene expression in pancreatic beta-cells.
L.Luo and N.Yano, Endocr. Res., 31, 185 (2005)
8.
Thyrotropin-releasing hormone (TRH), a signal peptide of the central nervous system.
H.Heuer et al., Acta Med. Austriaca, 26, 119 (1999)
9.
Decreased mononuclear leukocyte TSH responsiveness in patients with major depression.
D.V.Harbour et al., Biol. Psychiatry, 23, 797 (1988)
10.
Thyrotropin-releasing hormone selectively stimulates human hair follicle pigmentation.
E.Gaspar et al., J. Invest. Dermatol., 131, 2368 (2011)
11.
Evolutionarily conserved TRH neuropeptide pathway regulates growth in Caenorhabditis elegans.
Van Sinay E, et al. Proc Natl Acad Sci U S A. 2017 May 16;114(20):E4065-E4074. |
