| CAS | 190836-86-3 |
| Sequence | Pyr-His-Pro-AMC |
| Sequence Single | pEHP-AMC |
| Molecular Formula | C26H28N6O6 |
| Molecular Weight | 520.55 |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Description | TRH-AMC is a fluorogenic substrate used in in a coupled assay for TRH-degrading ectoenzyme. TRH-degrading ectoenzyme removes N-terminal pyroglutamic acid which yields His-Pro-AMC, a substrate for the coupled enzyme DPPIV. |
| References | 1. X-ray structures of human neutrophil collagenase complexed with peptide hydroxamate and peptide thiol inhibitors. Implications for substrate binding and rational drug design. F.Grams et al., Eur. J. Biochem., 228, 830 (1995) |