| CAS | 73644-58-3 |
| Sequence | Pyr-His-Pro-βNA |
| Sequence Single | pEHP-βNA |
| Molecular Formula | C26H28N6O4 |
| Molecular Weight | 488.55 |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Description | TRH-βNA is a sensitive and highly specific substrate for a rapid assay of rat brain TRH-deamidating enzyme (prolyl endopeptidase). TRH-βNA is also hydrolyzed by another TRH-degrading enzyme, pyroglutamyl peptidase II (thyroliberinase), which seems to play a key role in terminating the biological activity of neuronally released TRH. |
| References | 1. Bioactive cyclic dipeptides. C.Prasad, Peptides, 16, 151 (1995) 2. Rabbit Brain Pyroglutamyl Peptidase II, A Membrane-bound TRH Degrading Enzyme. S.Wilk and E.K.Wilk, Ann. N. Y. Acad. Sci., 553, 556 (1989) 3. New fluorogenic substrates for a rat brain proline endopeptidase. W.L.Taylor et al., Anal. Biochem., 105, 58 (1980) 4. Catabolism of neuropeptides by a brain proline endopeptidase. W.L.Taylor and J.E.Dixon, Biochem. Biophys. Res. Commun., 94, 9 (1980) 5. The Use of Analogues of TRH to Probe the Specificity of Pyroglutamyl Peptidase II. R.Lanzara et al., Ann. N. Y. Acad. Sci., 553, 559 (1989) 6. Specific fluorogenic substrates for the TRF-deamidating post proline cleaving enzyme. H.Knisatschek et al., FEBS Lett., 111, 157 (1980) |