| CAS | 137339-65-2 |
| Sequence | H-Ser-Phe-Leu-Leu-Arg-Asn-Pro-Asn-Asp-Lys-Tyr-Glu-Pro-Phe-OH |
| Sequence Single | SFLLRNPNDKYEPF |
| Molecular Formula | C81H118N20O23 |
| Molecular Weight | 1739.95 |
| Synonyms | Thrombin Receptor Activator Peptide 14, PAR-1 (1-14) (human), Proteinase Activated Receptor 1 (1-14) (human), Thrombin Receptor (1-14) (human), Coagulation Factor II Receptor (1-14) (human), Thrombin Related Peptide |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | Cardiovascular System & Diseases|Hematology |
| Description | TRAP-14 also called Thrombin Receptor Activator Peptide 14, PAR-1 (1-14) (human), Proteinase Activated Receptor 1 (1-14) (human), Thrombin Receptor (1-14) (human), Coagulation Factor II Receptor (1-14) (human), Thrombin Related Peptide, is a synthetic, potent thrombin receptor activator as well as an effective agonist for platelet activation. |
| References | 1. Tethered ligand agonist peptides. Structural requirements for thrombin receptor activation reveal mechanism of proteolytic unmasking of agonist function. R.M.Scarborough et al., J. Biol. Chem., 267, 13146 (1992) 2. Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation. T.-K.H.Vu et al., Cell, 64, 1057 (1991) 3. Thrombin receptor 14-amino acid peptide mediates endothelial hyperadhesivity and neutrophil adhesion by P-selectin-dependent mechanism. Sugama Y, et al. Circ Res. 1992 Oct;71(4):1015-9. 4. Structure-activity studies of the thrombin receptor activating peptide. Sabo T, et al. Biochem Biophys Res Commun. 1992 Oct 30;188(2):604-10. 5. Thrombin receptor agonist peptide decreases thrombomodulin activity in cultured human umbilical vein endothelial cells. Maruyama Y, et al. Biochem Biophys Res Commun. 1994 Mar 30;199(3):1262-9. |