| CAS | 141923-36-6 |
| Sequence | H-Ser-Phe-Leu-Leu-Arg-Asn-Pro-Asn-Asp-Lys-Tyr-Glu-Pro-Phe-NH2 |
| Sequence Single | SFLLRNPNDKYEPF-NH2 |
| Molecular Formula | C81H119N21O22 |
| Molecular Weight | 1738.96 |
| Synonyms | Thrombin Receptor Activator Peptide 14 amide, Proteinase Activated Receptor 1 (1-14) amide (human), PAR-1 (1-14) amide (human), Thrombin Receptor (1-14) amide (human), Coagulation Factor II Receptor (1-14) amide (human) |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | Hematology|Nitric Oxide Research |
| Description | TRAP-14 amide also called Thrombin Receptor Activator Peptide 14 amide, Proteinase Activated Receptor 1 (1-14) amide (human), PAR-1 (1-14) amide (human), Thrombin Receptor (1-14) amide (human), Coagulation Factor II Receptor (1-14) amide (human), has been shown to inhibit monocyte spreading on fibronectin-coated slides. The rapidly induced withdrawal of pseudopodial processes and rounding of the cells is accompanied by nitric oxide and endothelin-1 release. Spreading might be inhibited by autocrine endothelin-1 release and subsequent endothelin B receptor-dependent nitric oxide production. |