PeptideDB

Toxic Shock Syndrome Toxin-1 (TSST-1) (58-78)

CAS No.: 137593-46-5

Toxic Shock Syndrome Toxin-1 (TSST-1) is a "superantigen" which binds to MHC class II molecules and induces stimulation
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CAS 137593-46-5
Sequence H-Lys-Gly-Glu-Lys-Val-Asp-Leu-Asn-Thr-Lys-Arg-Thr-Lys-Lys-Ser-Gln-His-Thr-Ser-Glu-Gly-OH
Sequence Single KGEKVDLNTKRTKKSQHTSEG
Molecular Formula C98H171N33O35
Molecular Weight 2371.64
Technology Synthetic
Storage -20°C, avoid light, cool and dry place
Description Toxic Shock Syndrome Toxin-1 (TSST-1) is a "superantigen" which binds to MHC class II molecules and induces stimulation of T cells. Toxic Shock Syndrome Toxin-1 (TSST-1) (58-78) is a fragment of Toxic Shock Syndrome Toxin-1 (TSST-1), it has an active site of the TSST-1 holotoxin which binds to MHC class II molecules and is able to xenostimulate T cells in an MHC unrestricted manner. Therefore this peptide could be of great value in studying the immunobiology of MHC class II molecules.
References 1.  Transforming growth factor-alpha (TGF alpha) inhibition of parietal cell secretion: structural requirements for activity. J.R.Goldenring et al., Regul. Pept., 43, 37 (1993)