| CAS | 869988-94-3 |
| Sequence | H-Thr-Leu-Gln-Pro-Pro-Ala-Ser-Ser-Arg-Arg-Arg-His-Phe-His-His-Ala-Leu-Pro-Pro-Ala-Arg-OH |
| Sequence Single | TLQPPASSRRRHFHHALPPAR |
| Molecular Formula | C107H170N40O26 |
| Molecular Weight | 2432.78 |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Description | TLQP-21 (mouse, rat), a VGF-derived peptide endowed of endocrine and extraendocrine properties, is a potent G-protein-coupled receptor complement-3a receptor 1 (C3aR1) agonist (EC50: mouse TLQP-21=10.3 μM; human TLQP-21=68.8 μM). TLQP-21 activates C3aR1 to induce an increase of intracellular Ca2+. TLQP-21 is used for the research in regulation of nociception and other relevant physiologic functions. |
| References | 1. TLQP-21, A VGF-Derived Peptide Endowed of Endocrine and Extraendocrine Properties: Focus on In Vitro Calcium Signaling. Elena Bresciani , et al. Int J Mol Sci. 2019 Dec 24;21(1):130. 2. The TLQP-21 Peptide Activates the G-protein-coupled Receptor C3aR1 via a Folding-Upon-Binding Mechanism. Cheryl Cero, et al. ructure. 2014 Dec 2;22(12):1744-1753. |