| CAS | 207553-92-2 |
| Sequence | H-Met-Ser-Arg-Pro-Ala-Cys-Pro-Asn-Asp-Lys-Tyr-Glu-OH |
| Sequence Single | MSRPACPNDKYE |
| Molecular Formula | C58H91N17O20S2 |
| Molecular Weight | 1410.6 |
| Synonyms | T1 |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | Cardiovascular System & Diseases|Hematology |
| Description | Thrombin Receptor Antagonist also called T1, is based on the sequence of the thrombin receptor domain that functions as a tethered ligand for the receptor itself. Thrombin Receptor Antagonist has been selected from a phage peptide library as an inhibitor of thrombin triggered platelet aggregation, serotonin release and tyrosine phosphorylation. Its anti-aggregatory activity was about ten-fold higher than that of the previously reported peptide antagonists of the thrombin receptor. Thrombin Receptor Antagonist has served as model peptide in protein modification and MS studies. |