| CAS | 14636-12-5 |
| Sequence | H-Gly-Gly-Gly-Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Lys-Gly-NH2 (Disulfide bond) |
| Sequence Single | GGGCYFQNCPKG-NH2 |
| Molecular Formula | C52H74N16O15S2 |
| Molecular Weight | 1227.39 |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | Cardiovascular System & Diseases |
| Description | Terlipressin is a vasopressin analogue with potent vasoactive properties. Terlipressin is a highly selective vasopressin V1 receptor agonist that reduces the splanchnic blood flow and portal pressure and controls acute variceal bleeding. Terlipressin exerts anti-inflammatory and anti-oxidative effects. Terlipressin has the potential for hepatorenal syndrome and norepinephrine-resistant septic shock research. |
| References | 1. Thermal stability of rhodopsin and opsin in some novel detergents. W.J.de Grip, Meth. Enzymol., 81, 256 (1982) 2. Rescue treatment with terlipressin in children with refractory septic shock: a clinical study. A.Rodriguez-Nunez et al., Crit. Care, 10, R20 (2006) 3. Terlipressin as rescue treatment of refractory shock in a neonate. L.Filippi et al., Acta Paediatr., 97, 500 (2008) 4. Terlipressin Protects Intestinal Epithelial Cells Against Oxygen-Glucose Deprivation/Re-Oxygenation Injury via the Phosphatidylinositol 3-kinase Pathway. Zi-Meng Liu, et al. Exp Ther Med. 2017 Jul;14(1):260-266. 5. Refractory Torsade De Pointes Induced by Terlipressin (Glypressin). Yeun Tarl Fresner Ng Jao, et al. Int J Cardiol. 2016 Nov 1;222:135-140. 6. Signaling Through Hepatocyte Vasopressin Receptor 1 Protects Mouse Liver From Ischemia-Reperfusion Injury. Xiqiang Liu, et al. Oncotarget. 2016 Oct 25;7(43):69276-69290. 7. Terlipressin for the Treatment of Acute Variceal Bleeding: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Xinmiao Zhou, et al. Medicine (Baltimore). 2018 Nov;97(48):e13437. 8. Terlipressin for Norepinephrine-Resistant Septic Shock. Alastair O’Brien, et al. Lancet. 2002 Apr 6;359(9313):1209-10. |