PeptideDB

Tau Peptide (245-274) (Repeat 1 Domain)

CAS No.: 1428134-39-7

Tau Peptide (245-274) (Repeat 1 Domain) is the sequence adjacent to the aggregating PHF6* motif (VQIINK). In PHF-tau, N-
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CAS 1428134-39-7
Sequence H-Thr-Ala-Pro-Val-Pro-Met-Pro-Asp-Leu-Lys-Asn-Val-Lys-Ser-Lys-Ile-Gly-Ser-Thr-Glu-Asn-Leu-Lys-His-Gln-Pro-Gly-Gly-Gly-Lys-OH
Sequence Single TAPVPMPDLKNVKSKIGSTENLKHQPGGGK
Molecular Formula C136H230N40O42S
Molecular Weight 3129.63
Technology Synthetic
Storage -20°C, avoid light, cool and dry place
Application Tau Peptides
Description Tau Peptide (245-274) (Repeat 1 Domain) is the sequence adjacent to the aggregating PHF6* motif (VQIINK). In PHF-tau, N-methylation of Lys254 and Lys267 and phosphorylation of Ser262 was detected. If not methylated, Lys254 is an ubiquitinylation site.
References 1.  Dual modification of Alzheimer’s disease PHF-tau protein by lysine methylation and ubiquitylation: a mass spectrometry approach. P.Delobel et al., Am. J. Pathol., 172, 132 (2008)