| CAS | 2022956-62-1 |
| Sequence | Ac-D-Val-D-Gln-D-Ile-D-Val-D-Tyr-D-Lys-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-NH2 |
| Sequence Single | Ac-vqivykRRRRRRRRR-NH2 |
| Molecular Formula | C92H171N45O18 |
| Molecular Weight | 2195.66 |
| Synonyms | PHF6-R9 |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | Tau Peptides |
| Description | T-Peptide is a highly neurotoxic cell-permeable analog of PHF6. It can induces aggregation of Tau peptides. T-Peptide can be used for the research of human immunodeficiency virus (HIV) infection. T-peptide prevents cellular immunosuppression and improves survival rate in septic mice. T-peptide also can inhibit the growth of residual tumor cells after surgical resection. |
| References | 1. Protein sequence and mass spectrometric analyses of tau in the Alzheimer’s disease brain. M.Hasegawa et al., J. Biol. Chem., 267, 17047 (1992) 2. Neuron-selective toxicity of tau peptide in a cell culture model of neurodegenerative tauopathy: essential role for aggregation in neurotoxicity. K.Zhao et al., J. Neurosci. Res., 88, 3399 (2010) 3. Peptide T in the treatment of painful distal neuropathy associated with AIDS: results of a placebo-controlled trial. The Peptide T Neuropathy Study Group. Simpson DM, et, al. Neurology. 1996 Nov;47(5):1254-9. 4. Tuftsin-derived T-peptide prevents cellular immunosuppression and improves survival rate in septic mice. Gao YL, et, al. Sci Rep. 2015 Nov 18;5:16725. |