| CAS | 137201-62-8 |
| Sequence | H-Leu-Val-Val-Tyr-Pro-Trp-Thr-OH |
| Sequence Single | LVVYPWT |
| Molecular Formula | C45H64N8O10 |
| Molecular Weight | 877.04 |
| Synonyms | LVV-hemorphin-4, Spinorphin, bovine |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | Opioid Research |
| Description | Spinorphin (bovine) also called LVV-hemorphin-4, Spinorphin, bovine, is an inhibitor of enkephalin-degrading enzymes. Spinorphin inhibits aminopeptidase, dipeptidyl aminopeptidase III, angiotensin-converting enzyme and enkephalinase. Spinorphin possesses an antinociceptive effect. |
| References | 1. Synthesis, biological evaluation and structural characterization of novel glycopeptide analogues of nociceptin N/OFQ. G.Arsequell et al., Org. Biomol. Chem., 9, 6133 (2011) 2. Spinorphin as an endogenous inhibitor of enkephalin-degrading enzymes: roles in pain and inflammation. Y.Yamamoto et al., Curr. Protein Pept. Sci., 3, 587 (2002) 3. Inhibitory effects of spinorphin, a novel endogenous regulator, on chemotaxis, O2- generation, and exocytosis by N-formylmethionyl-leucyl-phenylalanine (FMLP)-stimulated neutrophils. Y.Yamamoto et al., Biochem. Pharmacol., 54, 695 (1995) 4. Spinorphin, an endogenous inhibitor of enkephalin-degrading enzymes, potentiates leu-enkephalin-induced anti-allodynic and antinociceptive effects in mice. M Honda, et al. Jpn J Pharmacol. 2001 Dec;87(4):261-7. |