| CAS | 864084-88-8 |
| Sequence | H-Gln-Arg-Phe-Ser-Arg-OH |
| Sequence Single | QRFSR |
| Molecular Formula | C29H48N12O8 |
| Molecular Weight | 692.78 |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | Opioid Research |
| Description | Opiorphin is a modulator of mood-related states and pain sensation. The pain-suppressive potency is as effective as morphine in the pin-pain test, a behavioral rat model of acute mechanical pain. Opiorphin is a potent enkephalin-inactivating zinc ectopeptidases in human inhibitor. Opiorphin inhibits two enkephalin-catabolizing ectoenzymes, human neutral ecto-endopeptidase, hNEP (EC 3.4.24.11) with an IC50 value of 11 μM, and human ecto-aminopeptidase, hAP-N (EC 3.4.11.2). Opiorphin displays potent analgesic activity by activating endogenous opioid-dependent transmission. |