| CAS | 73032-94-7 |
| Sequence | H-Ser-Ala-Asn-Ser-Asn-Pro-Ala-Met-Ala-Pro-Arg-Glu-Arg-Lys-Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys-OH (Disulfide bond) |
| Sequence Single | SANSNPAMAPRERKAGCKNFFWKTFTSC |
| Molecular Formula | C137H207N41O39S3 |
| Molecular Weight | 3148.6 |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | Gastrointestinal Research |
| Description | The octacosapeptide somatostatin-28 arises from the posttranslational cleavage of prosomatostatin, which in turn is derived from a larger precursor, preprosomatostatin. Somatostatin-28 was first isolated from porcine duodenum. In guinea-pig pancreatic acini, somatostatin-28, unlike somatostatin-14, increased amylase secretion, cellular cyclic GMP, and Ca2+ outfluxes. |
| References | 1. Identification and quantification of Gi-type GTP-binding proteins that copurify with a pituitary somatostatin receptor. D.R.Luthin et al., J. Biol. Chem., 268, 5990 (1993) 2. Somatostatin 28 interacts with CCK receptor in brain and pancreas. N.Tahiri-Jout et al., Neuropeptides, 19, 65 (1991) 3. Isolation and structure of pro-somatostatin: a putative somatostatin precursor from pig hypothalamus. A.V.Schally et al., Proc. Natl. Acad. Sci. USA, 77, 4489 (1980) 4. N-terminally extended somatostatin: the primary structure of somatostatin-28. L.Pradayrol et al., FEBS Lett., 109, 55 (1980) 5. Somatostatin in Alzheimer’s disease and depression. G.Bissette and B.Myers, Life Sci., 51, 1389 (1992) |