| CAS | 110880-55-2 |
| Sequence | H-Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Sar-Leu-Met(O2)-NH2 |
| Sequence Single | RPKPQQFF-Sar-L(O2)-NH2 |
| Molecular Formula | C64H100N18O15S |
| Molecular Weight | 1393.68 |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Description | (Sar9,Met(O2)11)-Substance P is a NK-1 receptor agonist, it exhibits the highest selectivity for NK-1 receptors in various bioassays. It evokes a concentration-dependent increase in mucus secretion and is much more potent than substance P (EC50= 1.7 · 10-⁶M). |
| References | 1. Unique amino terminal structure of rat little gastrin. J.R.Reeve, Jr. et al., Peptides, 2, 453 (1981) 2. Ava[L-Pro9,N-MeLeu10] substance P(7-11) (GR 73632) and Sar9, Met(O2)11 increase distention-induced peristalsis through activation of neurokinin-1 receptors on smooth muscle and interstitial cells of cajal. F.Nieuwmeyer et al., J. Pharmacol. Exp. Ther., 317, 439 (2006) 3. Tachykinin control of ferret airways: mucus secretion, bronchoconstriction and receptor mapping. S.Meini et al., Neuropeptides, 24, 81 (1993) 4. Multiple neurokinin receptors: Recent developments. R.Quirion and T.V.Dam, Regul. Pept., 22, 18 (1988) 5. Characterization of central and peripheral effects of septide with the use of five tachykinin NK1 receptor antagonists in the rat. Cellier E, et al. Br J Pharmacol. 1999 Jun;127(3):717-28. |