| CAS | 80434-86-2 |
| Sequence | H-Arg-D-Pro-Lys-Pro-Gln-Gln-D-Trp-Phe-D-Trp-Leu-Met-NH2 |
| Sequence Single | RpKPQQwFwLM-NH2 |
| Molecular Formula | C74H106N20O13S |
| Molecular Weight | 1515.85 |
| Synonyms | [DPro2, DTrp7,9] Substance P |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Description | (D-Pro2,D-Trp7.9)-Substance P also called [DPro2, DTrp7,9] Substance P, is a CNS antagonist of substance P. Long-term administration of this antagonist to the eye inhibited the ocular response to infrared irradiations of the iris. |
| References | 1. A substance P antagonist, [D-Pro2, D-Trp7,9]SP, inhibits inflammatory responses in the rabbit eye. Holmdahl G, et al. Science. 1981 Nov 27;214(4524):1029-31. 2. The mechanism of action of a substance P antagonist (D-Pro2, D-Trp7,9)-SP. Håkanson R, et al. Br J Pharmacol. 1982 Dec;77(4):697-700. 3. Antiproliferative effects of [D-Pro2, D-Trp7,9]-Substance P and aprepitant on several cancer cell lines and their selectivity in comparison to normal cells. Matalińska J, et al. Folia Neuropathol. 2020;58(3):237-244. English. |