Sar-[D-Phe8]-des-Arg9-Bradykinin Various Peptides Catalog

CAS	126959-88-4
Sequence	H-Sar-Arg-Pro-Pro-Gly-Phe-Ser-Pro-D-Phe-OH
Sequence Single	Sar-RPPGFSP-D-Phe
Molecular Formula	C47H66N12O11
Molecular Weight	975.11
Technology	Synthetic
Storage	-20°C, avoid light, cool and dry place
Description	Sar-[D-Phe8]-des-Arg9-Bradykinin is a potent and selective bradykinin B1 receptor agonist (EC50 = 9.02 nM in rabbit aorta) that is resistant to aminopeptidase, kininase I and II (ACE) and neutral endopeptidase cleavage. Sar-[D-Phe8]-des-Arg9-Bradykinin exhibits hypotensive and angiogenic activity in vivo.
References	1. Hypotensive effects of Lys-des-Arg9-Bradykinin and metabolically protected agonists of B1 receptors for kinins. Drapeau et al (1991). J.Pharmacol.Exp.Ther. 259 997 PMID: 1662280 2. Development and in vivo evaluation of metabolically resistant antagonists of B1 receptors for kinins. Drapeau et al (1993). J.Pharmacol.Exp.Ther. 266 192 PMID: 8392550 3. International union of pharmacology. XLV. Classification of the kinin receptor family: from molecular mechanisms to pathophysiological consequences. Leeb-Lundberg et al (2005). Pharmacol.Rev. 57 27 PMID: 15734727

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