| CAS | 125911-68-4 |
| Sequence | H-His-Met-Arg-Ser-Ala-Met-Ser-Gly-Leu-His-Leu-Val-Lys-Arg-Arg-OH |
| Sequence Single | HMRSAMSGLHLVKRR |
| Molecular Formula | C74H131N29O18S2 |
| Molecular Weight | 1779.17 |
| Synonyms | (Ser77,Arg87.88)-ACC-α (74-88) (dephosphorylated) (bovine, ovine), (Ser76,Arg86.87)-ACC-α (73-87) (dephosphorylated) (E. coli, rat), (Ser77,Arg87.88)-Acetyl-CoA Carboxylase 1 (74-88) (dephosphorylated) (bovine, ovine), (Ser76,Arg86.87)-Acetyl-CoA Carboxyl |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Description | SAMS Peptide also called (Ser77,Arg87.88)-ACC-α (74-88) (dephosphorylated) (bovine, ovine), (Ser76,Arg86.87)-ACC-α (73-87) (dephosphorylated) (E. coli, rat), (Ser77,Arg87.88)-Acetyl-CoA Carboxylase 1 (74-88) (dephosphorylated) (bovine, ovine), (Ser76,Arg86.87)-Acetyl-CoA Carboxylase 1 (73-87) (dephosphorylated) (E. coli, rat), is a substrate for AMP-activated protein kinase (AMPK). Phosphorylated rapidly by AMPK, it is more specific for the kinase than acetyl CoA carboxylase itself, and provides a convenient and sensitive assay for AMPK. |
| References | 1. Purification and characterization of the AMP-activated protein kinase. Carling et al (1989). Eur.J.Biochem. 186 129 PMID: 2598924 2. Tissue distribution of the AMP-activated protein kinase, and lack of activation by cyclic-AMP-dependent protein kinase, studied using a specific and sensitive peptide assay. Davies et al (1989). Eur.J.Biochem. 186 123 PMID: 2574667 3. The AMP-activated/SNF1 protein kinase subfamily: metabolic sensors of the eukaryotic cell? Hardie et al (1998). Annu.Rev.Biochem 67 821 PMID: 9759505 |