(Pyr5,N-Me-Phe8,Sar9)-Substance P (5-11) Substance P, Fragments, Analogs, and Antagonists Catalog

CAS	77128-69-9
Sequence	Pyr-Gln-Phe-N-Me-Phe-Sar-Leu-Met-NH2
Sequence Single	pEQF-N-Me-F-Sar-LM-NH2
Molecular Formula	C43H61N9O9S
Molecular Weight	895.09
Synonyms	DiMe-C7, [Glp5, (Me)Phe8, Sar9] Substance P (5-11)
Technology	Synthetic
Storage	-20°C, avoid light, cool and dry place
Description	(Pyr5,N-Me-Phe8,Sar9)-Substance P (5-11) also called DiMe-C7, [Glp5, (Me)Phe8, Sar9] Substance P (5-11), is a Substance P analogue that has approximately the same effects as Substance P on neurokinin 1 receptor (NK1R) in rat brain, but with a much longer duration of action. (Pyr5,N-Me-Phe8,Sar9)-Substance P (5-11) selectively activates dopamine metabolism in the mesencephalon and midbrain cortex of the rat brain. (Pyr5,N-Me-Phe8,Sar9)-Substance P (5-11) also increases motor activity and induces recovery of cocaine-seeking behavior in rats.
References	1. Selective activation of mesolimbic and mesocortical dopamine metabolism in rat brain by infusion of a stable substance P analogue into the ventral tegmental area. Elliott PJ, et al. Brain Res. 1986 Jan 15;363(1):145-7. 2. Substance P analog, DiMe-C7: evidence for stability in rat brain and prolonged central actions. Eison AS, et al. Science. 1982 Jan 8;215(4529):188-90. 3. Infusion of the substance P analogue, DiMe-C7, into the ventral tegmental area induces reinstatement of cocaine-seeking behaviour in rats. Placenza FM, et al. Psychopharmacology (Berl). 2004 Dec;177(1-2):111-20.

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