| CAS | 148439-49-0 |
| Sequence | H-Lys-Thr-Asn-Met-Lys-His-Met-Ala-Gly-Ala-Ala-Ala-Ala-Gly-Ala-Val-Val-Gly-Gly-Leu-Gly-OH |
| Sequence Single | KTNMKHMAGAAAAGAVVGGLG |
| Molecular Formula | C80H138N26O24S2 |
| Molecular Weight | 1912.27 |
| Synonyms | Prion Protein Fragment (106-126), human |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | Apoptosis & Necrosis |
| Description | Prion Protein (106-126) (human) also called Prion Protein Fragment (106-126), human, a peptide fragment of prion, and can induct neuronal apoptosis, antiproteinase K digestion, fiber formation, and mediate the conversion of normal cellular prion protein (PrPc) into pathogenic isoform (PrPSc). Prion Protein 106-126 (human) is generally used as the model to investigate neural degeneration of prion disease. |
| References | 1. Neurotoxicity of a prion protein fragment. Forloni G, et, al. Nature. 1993 Apr 8; 362(6420): 543-6. 2. Human prion protein-mediated calcineurin activation induces neuron cell death via AMPK and autophagy pathway. Hong JM, et, al. Int J Biochem Cell Biol. 2020 Feb; 119: 105680. |
Prion Protein (106-126) (human)
CAS No.: 148439-49-0
Prion Protein (106-126) (human) also called Prion Protein Fragment (106-126), human, a peptide fragment of prion, and ca
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