| CAS | 1423381-07-0 |
| Sequence | Myr-Lys-Arg-Met-Lys-Val-Ala-Lys-Asn-Ala-Gln-OH |
| Sequence Single | Myr-KRMKVAKNAQ |
| Molecular Formula | C63H118N18O14S |
| Molecular Weight | 1383.8 |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Description | Pep2m, myristoylated is a cell-permeable, myristoylated form of pep2m. Pep2m, myristoylated is a peptide inhibitor of the interaction between the C-terminus of the GluA2 (AMPA receptor) subunit and N-ethylmaleimide-sensitive fusion protein (NSF), a protein that regulates AMPA receptor function. Pep2m, myristoylated reduces postsynaptic currents in CA1 neurons, AMPA-mediated currents in cultured hippocampal neurons and AMPA receptor surface expression. |
| References | 1. NSF binding to GluR2 regulates synaptic transmission. Nishimune et al (1998). Neuron 21 87 PMID: 9697854 2. Surface expression of AMPA receptors in hippocampal neurons is regulated by an NSF-dependent mechanism. Noel et al (1999). Neuron 23 365 PMID: 10399941 3. Hippocampal LTD expression involves a pool of AMPARs regulated by the NSF-GluR2 interaction. Luthi et al (1999). Neuron 24 389 PMID: 10571232 4. Role of AMPA receptor cycling in synaptic transmission and plasticity. Luscher et al (1999). Neuron 24 649 PMID: 10595516 5. PKMz maintains late long-term potentiation by N-ethylmaleimide-sensitive factor/GluR2-dependent trafficking of postsynaptic AMPA receptors. Yao et al (2008). J.Neurosci. 28 7820 PMID: 18667614 |