| CAS | 328944-75-8 |
| Sequence | H-Tyr-Asn-Val-Tyr-Gly-Ile-Glu-Ser-Val-Lys-Ile-OH |
| Sequence Single | YNVYGIESVKI |
| Molecular Formula | C60H93N13O18 |
| Molecular Weight | 1284.47 |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Description | pep2-SVKI is an inhibitor peptide corresponding to last 10 amino acids of the C-terminus of the GluA2 AMPA receptor subunit. pep2-SVKI disrupts binding of GluA2 (at the C-terminal PDZ site) with glutamate receptor interacting protein (GRIP), AMPA receptor binding protein (ABP) and protein interacting with C kinase (PICK1). pep2-SVKI increases amplitude of AMPA receptor-mediated currents and blocks long-term depression (LTD). |
| References | 1. Functional roles of protein interactions with AMPA and kainate receptors. Collingridge and Isaac (2003). Neurosci.Res. 47 3 PMID: 12941441 2. PDZ proteins interacting with C-terminal GluR2/3 are involved in a PKC-dependent regulation of AMPA receptors at hippocampal synapses. Daw et al (2000). Neuron 28 873 PMID: 11163273 3. Interaction of the AMPA receptor subunit GluR2/3 with PDZ domains regulates hippocampal long-term depression. Kim et al (2001). Proc.Natl.Acad.Sci.U.S.A. 98 11725 PMID: 11573007 4. AMPA receptor-PDZ interactions in facilitation of spinal sensory synapses. Li et al (1999). Nat.Neurosci. 2 972 PMID: 10526335 |