| CAS | 794466-43-6 |
| Sequence | Rhodamine B-Gln-Arg-Leu-Phe-Gln-Val-Lys-Gly-Arg-Arg-OH |
| Sequence Single | Rhodamine B-QRLFQVKGRR |
| Molecular Formula | C84H126N24O15 |
| Molecular Weight | 1712.1 |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Description | PBP 10 is a selective formyl peptide receptor 2 (FPR2) antagonist; PBP 10 is cell permeable. PBP 10 selectively inhibits FPR2-mediated NADPH oxidase activity but has no effect on FPR1 signaling in neutrophils. PBP 10 displays PIP2 binding activity in vitro and blocks cell motility. PBP 10 also exhibits antiviral activity against influenza viruses via inhibition of viral-induced ERK activation. |
| References | 1. Cell permeant polyphosphoinositide-binding peptides that block cell motility and actin assembly. Cunningham et al (2011). J.Biol.Chem. 276 43390 PMID: 11533030 2. Structural characterization and inhibitory profile of formyl peptide receptor 2 selective peptides descending from a PIP2-binding domain of gelsolin. Forsman et al (2012). J.Immunol. 189 629 PMID: 22706076 3. Antiviral activity of formyl peptide receptor 2 antagonists against influenza viruses. Courtin et al (2017). Antiviral.Res. 5 252 PMID: 28483551 |