CAS | 225779-44-2 |
Sequence | H-Gly-Tyr-Pro-Gly-Gln-Val-OH |
Sequence Single | GYPGQV |
Molecular Formula | C28H41N7O9 |
Molecular Weight | 619.68 |
Synonyms | GYPGQV, Proteinase Activated Receptor 4 (1-6) (human), Thrombin Receptor-Like 3 (1-6) (human), Coagulation Factor II Receptor-Like 3 (1-6) (human) |
Technology | Synthetic |
Storage | -20°C, avoid light, cool and dry place |
Application | Hematology |
Description | PAR-4 (1-6) (human) also called GYPGQV, Proteinase Activated Receptor 4 (1-6) (human), Thrombin Receptor-Like 3 (1-6) (human), Coagulation Factor II Receptor-Like 3 (1-6) (human), corresponds to the amino terminus of the fourth protease-activated receptor (PAR4) after the cleavage at Arg47/Gly48, it was tested for its ability to stimulate COS cells expressing PAR4. PAR-4 (1-6) (human) readily activated both wild-type and mutant PAR4 (R47A) at 500 µM, whereas thrombin and trypsin only activate the wild-type PAR4. |
References | 1. Dipeptidyl-peptidase IV-beta, a novel form of cell-surface-expressed protein with dipeptidyl-peptidase IV activity. E.Jacotot et al., Eur. J. Biochem., 239, 248 (1996) 2. Cloning and characterization of human protease-activated receptor 4. W.-F.Xu et al., Proc. Natl. Acad. Sci. USA, 95, 6642 (1998) 3. The two-receptor system PAR-1/PAR-4 mediates alpha-thrombin-induced [Ca(2+)](i) mobilization in human astrocytoma cells. R.Kaufmann et al., J. Cancer Res. Clin. Oncol., 126, 91 (2000) 4. Protease-activated receptor 1 is the primary mediator of thrombin-stimulated platelet procoagulant activity. H.Andersen et al., Proc. Natl. Acad. Sci. USA, 96, 11189 (1999) |