| CAS | 171436-38-7 |
| Sequence | H-Ser-Leu-Ile-Gly-Arg-Leu-NH2 |
| Sequence Single | SLIGRL-NH2 |
| Molecular Formula | C29H56N10O7 |
| Molecular Weight | 656.83 |
| Synonyms | SLIGRLamide, Proteinase Activated Receptor 2 (1-6) amide (mouse, rat), Thrombin Receptor-Like 1 (1-6) amide (mouse, rat), Coagulation Factor II Receptor-Like 1 (1-6) amide (mouse, rat), SLIGRL-NH2 Protease-Activated Receptor 2 (PAR2) Agonist |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | Hematology |
| Description | PAR-2 (1-6) amide (mouse, rat) also called SLIGRLamide, Proteinase Activated Receptor 2 (1-6) amide (mouse, rat), Thrombin Receptor-Like 1 (1-6) amide (mouse, rat), Coagulation Factor II Receptor-Like 1 (1-6) amide (mouse, rat), SLIGRL-NH2 Protease-Activated Receptor 2 (PAR2) Agonist, is a protease-activated receptor-2 (PAR2) selective agonist. |
| References | 1. Purification and Some Properties of a Protease from the Sarcocarp of Musk Melon Fruit. M.Kaneda et al., Biosci. Biotechnol. Biochem., 61, 2100 (1997) 2. Rat proteinase-activated receptor-2 (PAR-2): cDNA sequence and activity of receptor-derived peptides in gastric and vascular tissue. M.Saiffeddine et al., Br. J. Pharmacol., 118, 521 (1996) 3. The protease-activated receptor-2 upregulates keratinocyte phagocytosis. E.R.Sharlow et al., J. Cell Sci., 113, 3093 (2000) 4. Proteinase-activated receptor-2 in rat aorta: structural requirements for agonist activity of receptor-activating peptides. M.D.Hollenberg et al., Mol. Pharmacol., 49, 229 (1996) 5. Detection of functional receptors for the proteinase-activated-receptor-2-activating polypeptide, SLIGRL-NH2, in rat vascular and gastric smooth muscle. B.al-Ani et al., Can. J. Physiol. Pharmacol., 73, 1203 (1995) 6. Proteinase activated receptor 2: Role of extracellular loop 2 for ligand-mediated activation. B.Al-Ani et al., Br. J. Pharmacol., 128, 1105 (1999) 7. Behavioral model of itch, alloknesis, pain and allodynia in the lower hindlimb and correlativeresponses of lumbar dorsal horn neurons in the mouse. Akiyama T, et al. Neuroscience. 2014 Apr 25;266:38-46. 8. Perivascular adipose tissue-derived relaxing factors: release by peptide agonists via proteinase-activated receptor-2 (PAR2) and non-PAR2 mechanisms. Li Y, et al. Br J Pharmacol. 2011 Dec;164(8):1990-2002. |
PAR-2 (1-6) amide (mouse, rat)
CAS No.: 171436-38-7
PAR-2 (1-6) amide (mouse, rat) also called SLIGRLamide, Proteinase Activated Receptor 2 (1-6) amide (mouse, rat), Thromb
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