| CAS | 165190-42-1 |
| Sequence | H-Tyr-Ile-Tyr-Gly-Ser-Phe-Lys-OH |
| Sequence Single | YIYGSFK |
| Molecular Formula | C44H60N8O11 |
| Molecular Weight | 877.01 |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | Protein-Tyrosine Kinases |
| Description | p60c-src Substrate is a octapeptide with the sequence of YIYGSFK selected from a random combinatorial peptide library. p60c-src Substrate is an efficient and specific substrate for p60c-src protein tyrosine kinase (PTK). p60c-src Substrate can be used to synthesize chimeric branched peptides. Its Km value for p60 c-src (55 µM) is about 6.4-fold lower than that of the cdc2 (6-20) substrate. |
| References | 1. Potent pseudosubstrate-based peptide inhibitors for p60(c-src) protein tyrosine kinase. Lou Q, et al. Cancer Res. 1997 May 15;57(10):1877-81. 2. Synthesis and evaluation of 3-phenylpyrazolo[3,4-d]pyrimidine-peptide conjugates as Src kinase inhibitors. Kumar A, et al. ChemMedChem. 2007 Sep;2(9):1346-60. |