| Sequence | H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Gly-Gly-Asp-Leu-Leu-Pro-Arg-Gly-Ser-NH2 |
| Sequence Single | YGRKKRRQRRRGGDLLPRGS-NH2 |
| Molecular Formula | C100H179N45O25 |
| Molecular Weight | 2411.8 |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Description | P110 is a dynamin-related protein 1 (Drp1) inhibitor, inhibits Drp1 GTPase activity. P110 displays no effect on dynamin 1 or other mitochondrial dynamics-related proteins. P110 inhibits mitochondrial fission, dysfunction and reactive oxygen species (ROS) production in vitro. P110 reduces programmed cell death and improves cell viability by protecting mitochondrial integrity. P110 reduces mitochondrial fragmentation and mitochondrial ROS production in mouse model of Parkinson’s disease. P110 is cell permeable. |
| References | 1. A novel Drp1 inhibitor diminishes aberrant mitochondrial fission and neurotoxicity. Qi et al (2013). J.Cell Sci. 126 789 PMID: 23239023 2. Inhibition of Drp1 mitochondrial translocation provides neural protection in dopaminergic system in a Parkinson’s disease model induced by MPTP. Filichia et al (2016). Sci.Rep. 13 32656 PMID: 27619562 |