| CAS | 848644-86-0 |
| Sequence | H-His-Ser-Asp-Val-His-Lys-NH2 |
| Sequence Single | HSDVHK-NH2 |
| Molecular Formula | C30H48N12O9 |
| Molecular Weight | 720.78 |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Description | P11 is a potent antagonist of the integrin αvβ3-vitronectin interaction (IC50 = 25.72 nM). Blocks proliferation and induces apoptosis in HUVECs; antiangiogenic. |
| References | 1. High-throughput screening of novel peptide inhibitors of an integrin receptor from the hexapeptide library by using a protein microarray chip. Lee et al (2004). J.Biomol.Screen. 9 687 PMID: 15634795 2. Site-specific inhibition of integrin alpha v beta 3-vitronectin association by a ser-asp-val sequence through an Arg-Gly-Asp-binding site of the integrin. Choi et al (2010). Proteomics 10 72 PMID: 19882657 3. Pharmacoproteomic analysis of a novel cell-permeable inhibitor of tumor-induced angiogenesis. Bang et al (2011). Mol.Cell Proteomics 10 M110 PMID: 21558493 |