| CAS | 610273-01-3 |
| Sequence | H-Ile-Leu-Lys-Gln-Ser-Met-Thr-Leu-Asn-Leu-Ala-Asp-Pro-Val-Gly-Ser-Leu-Lys-Pro-His-Leu-Arg-Ala-Lys-Asn-OH |
| Sequence Single | ILKQSMTLNLADPVGSLKPHLRAKN |
| Molecular Formula | C121H210N36O34S |
| Molecular Weight | 2743.55 |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Description | c-JUN peptide is a peptide comprising residues 33 - 57 of the JNK binding (δ) domain of human c-Jun. c-JUN peptide disrupts JNK/c-Jun interaction leading to inhibition of serum-induced c-Jun phosphorylation, up-regulation of p21cip/waf and modulation of inflammatory gene expression. c-JUN peptide specifically induces apoptosis in HeLa tumor cells. |
| References | 1. Disruption of the c-JUN-JNK complex by a cell-permeable peptide containing the c-JUN d domain induces apoptosis and affects a distinct set of interleukin-1 induced inflammatory genes. Holzberg et al (2003). J.Biol.Chem. 278 40213 PMID: 12832416 |