(p-Chloro-D-Phe6,Leu17)-VIP (human, mouse, rat) VIP, Prepro VIP, Analogs and Fragments Catalog

CAS	102805-45-8
Sequence	H-His-Ser-Asp-Ala-Val-p-chloro-D-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Leu-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn-NH2
Sequence Single	HSDAV-p-chloro-fTDNYTRLRKQLAVKKYLNSILN-NH2
Molecular Formula	C148H239ClN44O42
Molecular Weight	3342.25
Synonyms	[(4Cl)DPhe6, Leu17] VIP
Technology	Synthetic
Storage	-20°C, avoid light, cool and dry place
Description	(p-Chloro-D-Phe6,Leu17)-VIP (human, mouse, rat) also called [(4Cl)DPhe6, Leu17] VIP, is a competitive and selective antagonist of vasoactive intestinal peptide (VIP) receptor, with the IC50 of 125.8 nM. (p-Chloro-D-Phe6,Leu17)-VIP (human, mouse, rat) has no activity on glucagon, secretin or GRF receptors.
References	1. Characterization of VIP receptor-effector system antagonists in rat and mouse peritoneal macrophages. Pozo D, et, al. Eur J Pharmacol. 1997 Mar 5; 321(3): 379-86. 2. Vasoactive intestinal peptide receptor antagonist [4Cl-D-Phe6, Leu17] VIP. Pandol SJ, et, al. Am J Physiol. 1986 Apr; 250 (4 Pt 1): G553-7. 3. Regulation of exocrine pancreatic secretion by cerebral TRH and CGRP: role of VIP, muscarinic, and adrenergic pathways. Messmer B, et, al. Am J Physiol. 1993 Feb; 264(2 Pt 1): G237-42.

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