| CAS | 137348-10-8 |
| Sequence | H-Thr-Arg-Ser-Ala-Trp-Leu-Asp-Ser-Gly-Val-Thr-Gly-Ser-Gly-Leu-Glu-Gly-Asp-His-Leu-Ser-Asp-Thr-Ser-Thr-Thr-Ser-Leu-Glu-Leu-Asp-Ser-Arg-OH |
| Sequence Single | TRSAWLDSGVTGSGLEGDHLSDTSTTSLELDSR |
| Molecular Formula | C142H228N42O58 |
| Molecular Weight | 3451.62 |
| Synonyms | pTH-Related Protein (107-139) (human), Hypercalcemia of Malignancy Factor (107-139) (human) |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | Osteoporosis Research |
| Description | Osteostatin (human) also called pTH-Related Protein (107-139) (human), Hypercalcemia of Malignancy Factor (107-139) (human), is the carboxyl-terminal fragment of pTHrP, it is a potent inhibitor of osteoclastic bone resorption. It is suggested that this product acts directly on osteoclasts. |
| References | 1. Spatial and temporal expression of parathyroid hormone-related protein during wound healing. E.A.G.Blomme et al., J. Invest. Dermatol., 112, 788 (1999) 2. A potent inhibitor of osteoclastic bone resorption within a highly conserved pentapeptide region of parathyroid hormone-related protein; PTHrP[107-111]. A.J.Fenton et al., Endocrinology, 129, 3424 (1991) 3. A carboxyl-terminal peptide from the parathyroid hormone-related protein inhibits bone resorption by osteoclasts. A.J.Fenton et al., Endocrinology, 129, 1762 (1991) 4. A potent inhibitor of osteoclastic bone resorption within a highly conserved pentapeptide region of parathyroid hormone-related protein; PTHrP[107-111]. A.J.Fenton et al., Endocrinology, 129, 3424 (1991) |