Osteogenic Growth Peptide (10-14) Osteogenic Growth Peptides Catalog

CAS	105250-85-9
Sequence	H-Tyr-Gly-Phe-Gly-Gly-OH
Sequence Single	YGFGG
Molecular Formula	C24H29N5O7
Molecular Weight	499.52
Synonyms	OGP (10-14)
Technology	Synthetic
Storage	-20°C, avoid light, cool and dry place
Application	Hematology\|Osteoporosis Research
Description	Osteogenic Growth Peptide (10-14) also called OGP (10-14), the C-terminal truncated pentapeptide of osteogenic growth peptide (OGP), retains the full OGP-like activity. Osteogenic Growth Peptide (10-14) is responsible for the binding to the OGP receptor and activates an intracellular Gi-protein-MAP kinase signaling pathway. Osteogenic Growth Peptide (10-14) is a potent mitogen and stimulator of osteogenesis and hematopoiesis. Osteogenic Growth Peptide (10-14) acts as a Src inhibitor.
References	1. Pharmacological properties of peptides derived from stromal cell-derived factor 1: study on human polymorphonuclear cells. N.Heveker et al., Mol. Pharmacol., 59, 1418 (2001) 2. Bioactive pseudopeptidic analogues and cyclostereoisomers of osteogenic growth peptide C-terminal pentapeptide, OGP(10-14). Chen YC, et al. J Med Chem. 2002;45(8):1624-1632. 3. Regulation of endochondral ossification by osteogenic growth peptide C-terminal pentapeptide [OGP(10-14)]. Chen Z, et al. Protein Pept Lett. 2009;16(9):1074-1080. 4. Bone and bone-marrow interactions: haematological activity of osteoblastic growth peptide (OGP)-derived carboxy-terminal pentapeptide. Mobilizing properties on white blood cells and peripheral blood stem cells in mice. Fazzi R, et al. Leuk Res. 2002;26(1). 5. The small peptide OGP(10-14) reduces proliferation and induces differentiation of TPO-primed M07-e cells through RhoA/TGFbeta1/SFK pathway. Battolla B, et al. Med Sci Monit. 2011;17(1):SC1-SC5.

PeptideDB

Osteogenic Growth Peptide (10-14)

CAS No.: 105250-85-9