| CAS | 170713-75-4 |
| Sequence | H-Phe-Gly-Gly-Phe-Thr-Gly-Ala-Arg-Lys-Ser-Ala-Arg-Lys-Leu-Ala-Asn-Gln-OH |
| Sequence Single | FGGFTGARKSARKLANQ |
| Molecular Formula | C79H129N27O22 |
| Molecular Weight | 1809.06 |
| Synonyms | Orphanin FQ |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | Opioid Research |
| Description | Nociceptin also called Orphanin FQ, is an endogenous agonist of the opioid receptor-like ORL1 receptor, acting as a potent anti-analgesic. |
| References | 1. Neuropeptide Y (18-36) is a competitive antagonist of neuropeptide Y in rat cardiac ventricular membranes. A.Balasubramaniam and S.Sheriff, J. Biol. Chem., 265, 14724 (1990) 2. Sensitivity of opioid receptor-like receptor ORL1 for chemical modification on nociceptin, a naturally occurring nociceptive peptide. Y.Shimohigashi et al., J. Biol. Chem., 271, 23642 (1996) 3. Isolation and structure of the endogenous agonist of opioid receptor-like ORL1 receptor. J.-C.Meunier et al., Nature, 377, 532 (1995) 4. Orphanin FQ acts as an anxiolytic to attenuate behavioral responses to stress. F.Jenck et al., Proc. Natl. Acad. Sci. USA, 94, 14854 (1997) 5. Nociceptin/orphanin FQ antagonizes lipopolysaccharide-stimulated proliferation, migration and inflammatory signaling in human glioblastoma U87 cells. Bedini A, et al. Biochem Pharmacol. 2017 Sep 15;140:89-104. |