| CAS | 158584-08-8 |
| Sequence | Mca-Arg-Pro-Lys-Pro-Tyr-Ala-Nva-Trp-Met-Lys(Dnp)-NH2 |
| Sequence Single | Mca-RPKPYA-Nva-WMK(Dnp)-NH2 |
| Molecular Formula | C79H105N19O19S |
| Molecular Weight | 1656.89 |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | Cancer Research|Inflammation Research |
| Description | NFF-2 is a FRET substrate with the sequence of Mca-Arg-Pro-Lys-Pro-Tyr-Ala-Nva-Trp-Met-Lys(Dnp)-NH2, it was hydrolyzed 60 times more rapidly by stromelysin 1 (MMP-3) (kcat/Km= 59400 M-1s-1) than by interstitial collagenase (MMP-1). However, it showed little discrimination between MMP-3, gelatinase A (MMP-2) (kcat/Km= 54000 M-1s-1), and gelatinase B (MMP-9) (kcat/Km= 55300 M⁻¹s⁻¹). Metalloelastase (MMP-12) digested NFF-2 with a kcat/Km of 243000 M-1s-1. |