| CAS | 383415-79-0 |
| Sequence | H-Trp-Tyr-Lys-His-Val-Ala-Ser-Pro-Arg-Tyr-His-Thr-Val-Gly-Arg-Ala-Ala-Gly-Leu-Leu-Met-Gly-Leu-OH |
| Sequence Single | WYKHVASPRYHTVGRAAGLLMGL |
| Molecular Formula | C119H183N35O28S |
| Molecular Weight | 2584.05 |
| Synonyms | NPW-23 (human) |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | Obesity Research|Pituitary & Hypothalamic Hormones |
| Description | Neuropeptide W-23 (human) also called NPW-23 (human), is an endogenous ligand of the G-protein-coupled receptors GPR7 and GPR8. It dose-dependently inhibited cAMP accumulation induced by forskolin in CHO-GPR7 and CHO-GPR8 cells, with IC50 values of 0.025 and 0.178 nM, respectively. Intracerebroventricular administration of neuropeptide W-23 (human) in rats increased food intake and stimulated prolactin release. |
| References | 1. Modulation of CaV1.2 calcium channel by neuropeptide W regulates vascular myogenic tone via G protein-coupled receptor 7. Ji L, et al. J Hypertens. 2015 Dec;33(12):2431-42. 2. Neuropeptide W increases mean arterial pressure as a result of behavioral arousal. Pate AT, et al. Am J Physiol Regul Integr Comp Physiol. 2013 Oct 1;305(7):R804-10. 3. Central neuropeptide W has anorexigenic effect in rats. Naso T, et al. J Anim Physiol Anim Nutr (Berl). 2014 Apr;98(2):228-34. |