| CAS | 230960-31-3 |
| Sequence | H-Ser-Leu-Ala-Ala-Pro-Gln-Arg-Phe-NH2 |
| Sequence Single | SLAAPQRF-NH2 |
| Molecular Formula | C40H65N13O10 |
| Molecular Weight | 888.03 |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Description | Neuropeptide SF (mouse, rat) is a neuropeptide FF receptor agonist (Ki values are 48.4 and 12.1 nM for NPFF1 and NPFF2, respectively). Neuropeptide SF (mouse, rat) potentiates the antinociceptive action of morphine in vivo and reverses the loss of morphine potency in tolerant animals. Also increases the amplitude of the sustained current of heterologously expressed acid sensing ion channel 3 (ASIC3) (EC50 ~ 50 μM). |
| References | 1. Effects of neuropeptide SF and related peptides on acid sensing ion channel 3 and sensory neuron excitability. Deval et al (2003). Neuropharmacology 44 662 PMID: 12668052 2. Facilitation of spinal mor. analgesia in normal and mor. tolerant animals by neuropeptide SF and related peptides. Jhamandas et al (2006). Peptides 27 953 PMID: 16515821 3. The actions of neuropeptide SF on the hypothalamic-pituitary-adrenal axis and behavior in rats. Miklós Jászberényi, et al. Regul Pept. 2014 Jan 10;188:46-51. 4. Quantitative autoradiographic distribution of NPFF1 neuropeptide FF receptor in the rat brain and comparison with NPFF2 receptor by using [125I]YVP and [(125I]EYF as selective radioligands. C Gouardères, et al. Neuroscience. 2002;115(2):349-61. |