| CAS | 412938-67-1 |
| Sequence | H-Ser-Phe-Arg-Asn-Gly-Val-Gly-Thr-Gly-Met-Lys-Lys-Thr-Ser-Phe-Gln-Arg-Ala-Lys-Ser-OH |
| Sequence Single | SFRNGVGTGMKKTSFQRAKS |
| Molecular Formula | C93H155N31O28S |
| Molecular Weight | 2187.51 |
| Synonyms | NPS (human) |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | Obesity Research |
| Description | Neuropeptide S (human) also called NPS (human), a neuropeptide, is a potent cognate neuropeptide S receptor (NPSR) agonist with EC50 of 9.4 nM. Neuropeptide S human can be used for Alzheimer’s disease (AD) research. It is involved in the modulation of arousal and fear responses. Lateral ventricle administration of NPS caused a significant decrease in food intake. |
| References | 1. Pharmacological Profiles of Peptide Drug Candidates for the Treatment of Alzheimer’s Disease. C.Adessi et al., J. Biol. Chem., 278, 13905 (2003) 2. Neuropeptide S: a neuropeptide promoting arousal and anxiolytic-like effects. Xu YL, et al. Neuron. 2004 Aug 19;43(4):487-97. |