| CAS | 312306-89-1 |
| Sequence | H-Phe-Arg-Val-Asp-Glu-Glu-Phe-Gln-Ser-Pro-Phe-Ala-Ser-Gln-Ser-Arg-Gly-Tyr-Phe-Leu-Phe-Arg-Pro-Arg-Asn-NH2 |
| Sequence Single | FRVDEEFQSPFASQSRGYFLFRPRN-NH2 |
| Molecular Formula | C141H203N41O38 |
| Molecular Weight | 3080.42 |
| Synonyms | NMU-25 (human) |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | Obesity Research |
| Description | Neuromedin U is a neuropeptide which is widely distributed in the gut and central nervous system. Initially isolated from porcine spinal cord it was named for its uterine contractile activity. In fasted rats neuromedin U expression in certain brain areas is lower than in fed rats. In animal studies with neuromedin-23 (rat) overnight food intake is significantly reduced indicating that neuromedin U may be a physiological regulator of food intake. IC50 values for the binding of neuromedin U-25 (human) to the human neuromedin U receptors NMU1R and NMU2R are 2.7 nM and 1.8 nM, respectively. |
| References | 1. Cloning, mRNA expression, and chromosomal mapping of mouse and human preprocortistatin. L.de Lecea, Genomics, 42, 499 (1997) 2. Occurrence and developmental pattern of neuromedin U-immunoreactive nerves in the gastrointestinal tract and brain of the rat. J.Ballesta et al., Neuroscience, 25, 797 (1988) 3. Neuromedin U is overexpressed in pancreatic cancer and increases invasiveness via the hepatocyte growth factor c-Met pathway. K.Ketterer et al., Cancer Lett., 277, 72 (2009) 4. Topographic localization of neuromedin U-like structures in the rat brain: an immunohistochemical study. M.Honzawa et al., Neuroscience, 23, 1103 (1987) |