| CAS | 1872435-02-3 |
| Sequence | Dnp-Gly-Pro-Leu-Gly-Met-Arg-Gly-Leu-NH2 |
| Sequence Single | Dnp-GPLGMRGL-NH2 |
| Molecular Formula | C40H64N14O12S |
| Molecular Weight | 965.1 |
| Synonyms | Dnp-(Leu421)-Collagen Type VIII α1 Chain (419-426) amide (human, mouse) |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | Cancer Research|Inflammation Research |
| Description | MMP-13 Substrate also called Dnp-(Leu421)-Collagen Type VIII α1 Chain (419-426) amide (human, mouse), is a highly sensitive and selective substrate for collagenase-3 (MMP-13) with a kcat/Km value of 4.22 · 10⁶ M-1s-1 (pH = 7.5, T = 37 °C). The kcat/Km value of human collagenase-3 for this synthetic peptide is 1344-, 11-, and 820-fold better than that of related MMPs stromelysin-1 (MMP-3), gelatinase B (MMP-9), and collagenase-1 (MMP-1), respectively. |
| References | 1. Overview of MMP-13 as a Promising Target for the Treatment of Osteoarthritis. Hu Q, Ecker M. Int J Mol Sci. 2021 Feb 9;22(4):1742. |