| CAS | 1802078-32-5 |
| Sequence | Mca-Ser-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-Lys(Dnp)-NH2 |
| Sequence Single | Mca-SEVNLDAEFK(Dnp)-NH2 |
| Molecular Formula | C68H89N15O26 |
| Molecular Weight | 1532.54 |
| Synonyms | Mca-(Asn670,Leu671)-APP770 (667-675)-Lys(Dnp) amide |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | Alzheimer’s Disease |
| Description | Mca-(Asn670,Leu671)-Amyloid β/A4 Protein Precursor770 (667-675)-Lys(Dnp) amide also called Mca-(Asn670,Leu671)-APP770 (667-675)-Lys(Dnp) amide, is a fluorogenic (FRET) substrate for pro-memapsin-2 containing the β-secretase site of the Swedish mutation of APP. The kinetic parameters of Mca-SEVNLDAEFK(Dnp) amide at pH 4.5 are Km = 4.5 µM and kcat = 0.25 min-1. |
| References | 1. P2Y12 regulates platelet adhesion/activation, thrombus growth, and thrombus stability in injured arteries. P.André et al., J. Clin. Invest., 112, 398 (2003) 2. Proteolytic activation of recombinant pro-memapsin 2 (Pro-beta-secretase) studied with new fluorogenic substrates. J.Ermolieff et al., Biochemistry, 39, 16263 (2000) 3. Proteolytic activation of recombinant pro-memapsin 2 (pro-beta-secretase) studied with new fluorogenic substrates. J.Ermolieff et al., Biochemistry, 39, 12450 (2000) |
Mca-(Asn670,Leu671)-Amyloid β/A4 Protein Precursor770 (667-675)-Lys(Dnp) amide
CAS No.: 1802078-32-5
Mca-(Asn670,Leu671)-Amyloid β/A4 Protein Precursor770 (667-675)-Lys(Dnp) amide also called Mca-(Asn670,Leu671)-APP770 (
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